10X Genomics Xenium

The Xenium Analyzer is a bioscience instrument that streamlines spatial biology experiments, a process that detects the cellular localization of hundreds of RNA strands within a tissue section without the need for conventional sequencing. This gives scientists and researchers a detailed map of gene expression patterns. Allowing them to navigate the genesis of human disease and the pathway to discovering therapies. Bay area biotech company, 10X Genomics, reached out to us to begin the development of their new product. StudioRed’s Industrial design efforts focused on making sure it was safe and accessible, it optimized work efficiency, and put all its technology into an all-in-one attractive form factor. The prominent color splashes around the unit ensures that touch points are clear and for the user and provides a user experience which requires minimal training. We also helped with the development of the graphics used in the UI. Our mechanical engineering team worked with 10X’s in-house engineering to develop and refine the mechanisms at most of the interaction points as well as develop the skins through to a production ready solution. Throughout the development, the system itself was being refined, so constant interaction to ensure cohesion between the 10X internals and StudioRed skins was paramount.

  • 10x Genomics
  • Industrial Design, Mechanical Engineering, Prototyping, Manufacturing
  • 2022

Engineering Overview

HUR Bottle Cap

It was paramount that we make the unloading and loading of reagents as easy, safe, and straightforward as possible. With design and engineering working together, we were able to create a design that simplified and improved the experience. After several prototypes, we found that pinching the front of the cap was the best way to keep the user’s fingers away from getting pinched. With that we added several design cues such as the top crown and color splashes so users know where they should be touching as well as knowing what reagents go in what slots. 

 

Door Hinge

Knowing that the Xenium would live in a biolab environment, we knew that the front door had to have a minimal swing out distance while still being easy to open and close. Our engineering team worked to design a custom Four Bar hinge that comes out about 6 inches, feels light, and locks at the top position to make sure it does not collapse when the unit is being serviced.

 

Concept through production

Apart from developing the mechanical movements, the mechanical engineering team worked on moving the Xenium into manufacturing. Through doing tolerance analysis, they were able to ensure that all of the parts fit well together while maintaining previous design requirements such as easy access to replaceable parts. Along with that we worked on making sure that all of the parts are moldable.